I think the cause of potential trouble is this: Carnitine, also called L-carnitine, helps your cells produce energy by breaking down fat. Great explanation. Adapted from: Crane FL. The other two changes I had made was to try and calm down and get better sleep. When it completely stops leaking – my guess is those are that experience ‘spontaneous’ recovery. Try taking it 100mg at a time.get used to it and then increase to 200mg after 4 weeks…then wait a month and go up to 3. I too have changed from CoQ10 to ubiquinol. Life Extensions recommends 100-150 mg of ubiquinol daily for adults over the age of 30. Warning about increasing glutamate and glutamine intake: the research Meirav linked is about hEDS. amzn_assoc_marketplace = "amazon"; The mitochondria produce energy by breaking down fuel, like pyruvate derived from sugar, step by step. It also is a good help for MCAS issues. Some doctors recommended as much as 200 mg per day. I’ve had sinus issues all my life…ME/CFS for 13. I had plenty of experiences of drugs or supplements before working for one or two days and done then too. Jill Carnahan recommends avoiding Amazon and buying direct from the manufacturer, if possible. Cheapest Chronic Rhinitis Symptoms Fatigue And Coq10 Dose Chronic Fatigue Syndrome You can order Chronic Rhinitis Symptoms Fatigue And Coq10 Dose Chronic Fatigue Syndrome after check, compare the values and check day for shipping. It seems to be a protective measure. The Nutrition Examination Research Digest (NERD) aims to provide rigorous, unbiased analysis of the latest It also may help your brain utilize neurotransmitters, serotonin, and glutamate, which can be out of balance in people with fibromyalgia (FMS) and chronic fatigue syndrome (CFS or ME/CFS). Make sure you don’t miss another  one by registering for our free ME/CFS and Fibromyalgia blogs here.. The first picture in it shows how these complexes cooperate. Since the reaction catalysed by complex I is NADH + H+ + CoQ + 4H+in→ NAD+ + CoQH2 + 4H+out (Wikipedia)), might supplementing with coq10 further upregulate this reaction leading to overburdening of the underperforming complex V downstream? I suspect that the CoQ10 gives an initial boost to the given energy pathways, but this puts added strain on other components and aspects of the pathways – which may also be depleted/disturbed in me/cfs sufferers – and so the sufferer feels worse or crashes. For many ME patients, both of these give first a quick burst of extra energy and then fire back. It comes immediately after I experience energy and feelings of real health. I also developed a massive problem with fructose, in 2007, when all this started after massive stress/flu and fructose is processed by the liver. We start to feel a little better, expend more energy again After reading some of the comments (as I can’t read too much info without it overtaxing my brain) it made me realize not only how complex this disease is, but also just how complex and wonderfully made the human body is – everything is so finely tuned to work perfectly as it was meant to, but because of imperfection it takes only one small thing to throw the whole thing out and stop it working as it should. can go longer ways, as I see it. Exercise fatigue refers to a serious drop in power and performance over time, often resulting in burnout. A larger (n=80) randomized, controlled, double-blinded Spanish trial found that a CoQ10/NADH mixture (50 mg CoQ10, 5 mg  NADH, 40 mg Vit. That finding, of course, suggested that those behavioral characteristics derive from high levels of oxidative stress and inflammation. Carnosine may have a variety of benefits, and this trial tested carnosine’s specific effect on insulin dynamics. Once again, zero effect. I had to quickly stop taking the oral rehydration solution because it was improving my health. I have tried CoQ10 on a number of occasions and every time had a bad reaction to it. It is often accompanied by cognitive difficulties, muscle and joint pain, depression, poor sleep quality, or other nonspecific symptoms (Cella 2011; Jones 2011; Ciccone 2010). Beam me up Scotty! Do probiotics actually change the makeup of our microbiomes? Studying your individual biochemistry may help (the use of plasma amino acids has been useful for me). I remember from previous discussions that some people may have a problem with Magnesium. Might that be an explanation (or partial explanation) for why some people with me/cfs have a negative reaction to COQ10? That may be another illustration that producing enough energy may not be the first problem in (a large amount of cases of) ME, but producing enough energy without too much damaging side effects. 300 mgs of CoQ10 daily (divided up into 3 doses) resulted in about 50% pain reduction, increased (but not normal) CoQ10 and ATP levels and normal lipid peroxidation (oxidative stress) levels. Thanks Meirav, I’ve signed up for Caroline’s blog – I had a quick look, as I’m fairly tired at the moment – she looks right up my street. Also, a cardiologist said he thinks it’s imperative for anyone taking a statin drug to also be taking Ubiquinol CoQ10 so people might want to ask their cardiologists about that. In fact, CoQ10 testing is rarely ordered unless a patient is suspected to have some sort of mitochondrial disease or unexplained chronic fatigue syndrome. It’s gotta be a huge drain….It’s not that everyone – healthy or not – doesn’t do this – it’s that consequences are so much worse, I believe, if you have energy production problems. CoQ10 protects cells against oxidative damage. I’m supposed to be taking a break myself! Thank you for bringing this up! Right, same experience, I do well on B2 (handle stress better) but feel bad in the evening. I usually initially get a slight boost in energy, but then unfortunately experience flu-like symptoms, so have to discontinue (even with low doses – I think I was only taking 30 mg once or twice a day). Stop wasting time and energy — we make it easy for you to stay on top of nutrition research. Maes (2011) found highly reduced CoQ10 levels in people with depression and chronic fatigue syndrome and tied the lower CoQ10 levels to cardiovascular and inflammatory issues in depression and ME/CFS. CoQ10 levels have also been found to be lower in people with certain conditions, such as heart disease.CoQ10 is found in meat, fish and whole grains. I have read that any product made by "tishcon" is quite good, and a friend who is a pharmacist maintains Sam's product is "absorbable enough". Even the smallest amount seems to overstimulate me. I already take a Vit B complex supplement, but perhaps I might try adding in some more B3. That is actually the first possible explanation that anyone has ever provided. And address reducing those high levels as well. A surprising number of different formulations have been created, with several showing promise. Rick explains the difference between A1 and A2 beta-casein, and what benefits may be associated with A2 milk. Hello – not quite on coQ10… One of “smart pioneer” woman Looneymom who discussed this bad high (excitatory) glutamine (and glycine) versus low (calming) GABA ratio seen by several patients with exciety problems. Can you please send coordinate at following correspondence: Those two things will help the mitochondria produce the desired ATP. In 2005, Maes found very low plasma CoQ10 levels in ME/CFS. Fascinating stuff! There are many anecdotal reports of its beneficial effects and CFS practitioners often prescribe it. Bigger studies would maybe reveal my sub-group. It also plays a vital role in producing the body’s primary source of energy, ATP. Thank you! I get the “Healthy Care” brand which is quite cheap in Australia. All three of these organs, the hypothalamus (a region of your brain), the pituitary gland (attached to the base of the hypothalamus) and the adrenal glands (which sit on top of your kidneys) play a role in regulating the stress response. (Ammonia) Reabsorption by the gut, or taking up the urea and ammonia again and again, is a problem when you have poor gut flora. )” CoQ10 is also used to reduce fatigue in patients with fibromyalgia. I’ve been working at it for years – trying to very slowly to achieve small improvements. I was scanning the numbers and said what’s the 168? Lack of oxygen can be one source. Yes, I do have some fatigue but not to the point I can hardly do anything. Creating forms of higher bioavailable CoQ10 is clearly a growth field. However, “the mitochondria” is not a single thing working in unison. What to do: In addition to getting tested for underlying infections, consider blends of Siberian ginseng, samento, sarsaparilla, guaiacum, astragalus, resveratrol, and cat's claw for their immune-strengthening properties. CoQ10 levels have been reported to decrease with age and are also frequently low in individuals with a variety of chronic diseases, such as various heart conditions, degenerative muscular conditions, Parkinson’s disease, cancer, diabetes, and HIV/AIDS. Solubilized formulations of CoQ10 do appear to be available. Carnitine is also an antioxidant. D-Ribose and CoQ10 are just two of the many nutrients that can help mitochondrial function. – alongside the nutraceuticals. Perhaps. CoQ10 also mops up free radicals produced during energy production inside the cell and is an ATP production enhancer. “When excessive amounts of ammonia enter the central nervous system, the brain’s defences are severely challenged. @dejurgen, I really relate to what you’re saying about high energy production being too damaging, and thanks for your car and conveyor belt analogies, they convey the concept well. One FM/ME/CFS physician … It can affect muscles as well. Cooling the Flames: Possible Approaches to Reducing Neuroinflammation in Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia, Future Drugs for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)? It also may help your brain utilize neurotransmitters, serotonin, and glutamate, which can be out of balance in people with fibromyalgia (FMS) and chronic fatigue syndrome (CFS or ME/CFS). – instead, focus in reducing cell stress, in the different ways in can be provoked and reducing the ‘toxic’ substances produced. As the nurse was taking my blood pressure, I could see the large screen on a wheeled pedestal. Take zinc 25 mg a day for three months, then 15 mg daily from then on, as chronic infections will routinely cause zinc deficiency and immune dysfunction. ), rosy cheeked and my blood pressure soared. It has now been shown that the extreme fatigue experienced by CFS/ME sufferers is a direct result of mitochondrial dysfunction (i.e. A Spanish group recently produced a broad overview of the field “Coenzyme Q10: Novel Formulations and Medical Trends“- with a focus on CoQ10 future prospects. These are just two of many theories. I do however, remember sinusitis being mentioned here before. out of the equation. Suggested doses for healthy people appear to be around 100 mg/day. I had no idea that mitochondria absent enough oxygen = lots of ROS. No matter how much rest they get, they just can’t seem to shake the extreme fatigue they feel. I’ll see my PCP in January, so this may possibly give me more avenues to investigate. Acetyl-L-Carnitine (ALC or ALCAR) and L-Carnitine help to transport nutrients for energy production into the mitochondria. No, I said. CoQ10 is a multipurpose molecule. CFS, also known as myalgic encephalomyelitis, is extreme tiredness which doesn’t improve with rest. Thank you for sharing it. I’m now 63. I started taking CoQ10, in March/April 2019, because I kept hearing about it from Dr Nancy Klimas, Dan Neuffer and Terry Wahls M.D. B3, which I always just thought of a useful distraction, seems to have about a 2 week efficacy life span, then I stop for a few days. This is rather lengthy with really good comments and lots of additional research linked in those comments. I do wonder if there is a small percentage of the ME/CFS population that is indeed not getting recognition for their inherited metabolic disorder. I still have immune issues – there’s no dialogue possible with General Immune. Early results suggest this approach may work with much lower levels of CoQ10 able to be used. CoQ10 produced significant reductions in fibromyalgia, Coenzyme Q10: Novel Formulations and Medical Trends, https://healthfully.com/supplements-dilate-blood-vessels-6615780.html, https://nutritionfacts.org/video/how-to-regenerate-coenzyme-q10-coq10-naturally/, https://www.youtube.com/watch?v=vWIGPylrGgg, https://chronicallycaroline.com/2019/06/02/keto-and-me-part-i-an-elevated-heart-rate/, https://chronicallycaroline.com/2019/12/18/10-tips-for-getting-started-on-a-ketogenic-diet-with-me-cfs/, https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.07.001, https://www.omf.ngo/2020/10/12/nitrogen-metabolism-and-testing-nitrogen-hypothesis-in-me-cfs/, https://www.ncbi.nlm.nih.gov/books/NBK541039/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657470, https://www.journal-of-hepatology.eu/article/S0168-8278(16)30474-3/pdf, https://www.meaction.net/2016/12/23/fluge-mella-and-armstrong-more-support-for-disordered-metabolism-in-me-patients/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714775/pdf/nihms-228735.pdf, https://www.healthrising.org/blog/2020/06/05/fight-flight-neuroinflammation-fibromyalgia-chronic-fatigue-syndrome/, https://www.healthrising.org/blog/2020/05/27/neuroinflammatory-paradigm-chronic-fatigue-me-cfs/, https://www.dinet.org/forums/topic/23706-pots-excitotoxicity/, https://www.biologydiscussion.com/respiration/electron-transport-system-and-oxidative-phosphorylation-in-mitochondria/23316, Hormones (thyroid, testosterone, progesterone, estrogen, hydrocortisone). CoQ10 does help produce two chemicals called NADH and FADH2. Needless to say, all these issues not only cause poor energy levels and fatigue but also other serious chronic problems. There isn’t nearly as much research on potential benefits of omega-6 fatty acids as there is on omega-3s. Nope. https://www.healthrising.org/blog/2019/08/12/brain-small-fiber-neuropathy-fibromyalgia-chronic-fatigue/, In 2018 Cort wrote an article on Simmaron that sparked a discussion about the risks of high glutamate in the comments. Increased levels of reactive oxygen species (free radicals) are one of the most consistent findings in ME/CFS and FM. So, the combination of complex I being sped up and complex IV being slowed down slows down the conversion of succinate to fumarate *a whole lot*. So it helps to “boost the mitochondria”. Are Intranasal Drugs the Future for ME/CFS and Fibromyalgia? That’s an interesting finding, given the possibly reduced blood flows in ME/CFS, and the no less than five studies since 2001 which have found increased levels of lipid oxidation and/or free radicals in the blood of people with ME/CFS. I’ve ME/CFS and is using 400 mg daily for the last 4-5 years. My muscles feel relaxed and supple – and then it comes – these flu-like feelings, joints sometimes start popping and this incredible lethargy…. I am in the energy produces side-effects category. (Issues with sulfur pathways, and that forms more ammonia.)”. You can barely get out of bed to take a shower or fix a simple meal. It is often accompanied by cognitive difficulties, muscle and joint pain, depression, poor sleep quality, or other nonspecific symptoms (Cella 2011; Jones 2011; Ciccone 2010). © 2011-2021 Examine.com Inc | Privacy | Terms of Service | Disclaimer | About Us | Contact Examine.com, Figure 1: CoQ10 content in food (per 120g serving), Atopic dermatitis, otherwise known as eczema, isn’t an easily treatable condition. the longer (and longer) the stays in PEM are, {per Cell Danger Response theory, as it is proposed}, – – – – – – – – – – – – – – – – Do probiotics alter gut microbiome composition? Findings like those generally set people up for increased risk of cardiovascular illness. CoQ10 is even thought to reduce some of the symptoms of old age. This also happens to me with other things that are supposed to give people energy and relieve pain — Alpha Lipoic Acid, Tumeric, etc. III. When I hear of someone severely ill, with seizures – my mind wonders: have they had a thorough workup for metabolic disorder and ruled it out before arriving at the clinical diagnoses of ME/CFS? hopefully less of it leaking out – Another hypothesis suggests[4] that some sort of immune abnormality is causing a pro-oxidative inflammatory response. It seems that in a large subgroup of ME patients the body wilfully and decisively shuts down the energy production in order to prevent this damage. => That is nothing but slowing down the entire Krebbs cycle a whole lot, as the conversion of succinate to fumarate is a necessary step in the conversion of pyruvate and acetyl-Coa in the Krebbs cycle. Again, the dose of CoQ10 in order to achieve a response has been worked out for cardiac patients and this varies from 200 mg to 600 mg daily. On https://www.healthrising.org/blog/2020/05/27/neuroinflammatory-paradigm-chronic-fatigue-me-cfs/ we describe things like: “Things like excessive extracellular glutamate, another key part in our hypothesis, are heavily modified by hypoxia. So all day, as I lay on the bed, quietly reading my book, feeling fairly relaxed, my blood pressure kept spiking. https://www.omf.ngo/2020/10/12/nitrogen-metabolism-and-testing-nitrogen-hypothesis-in-me-cfs/. I get an energy boost and then fall apart…So strange. Trying to shift metabolism towards anabolism more often is a potential approach – a slow one at that. There are days when you're happy, alert, and active. SEDDS – Lipid-free self-emulsifying drug delivery systems (SEDDS) which feature surfactants that reduce the surface tension of CoQ10 – allowing it to be more easily absorbed through the gut wall – appear to be effective. Most patients with chronic fatigue syndrome have below normal blood levels of Co enzyme Q10, according to a recent study published in the journal Neuroendocrinology Letters.. A Clinical Trials Survey. She and I are also trying to work on improving urea excretion through the gut. April 1, 2009 at 1:56 am; 26 replies; TODO: Email modal placeholder. Studies show that taking it in sufficient amounts for 4 weeks or so results in increased levels in the bloodstream. Now imagine feeling like this for six months straight, or even longer. I think the recommended dosage of many supplements is often too low for people like us who have problems. => IMO the better your oxygenation, pacing and the fewer you exhaust till PEM, the more chance coQ10 could benefit you. CFS is thought to afflict 0.26 to 0.78%[1] of the U.S. population, roughly 800,000 to 2.5 million people. ), Many of us tried GABA and precursor to it like glycine and glutamine and even glutathione trying to up our GABA, but had quite the opposite outcome and upped our glutamate even more. – may ‘suck it up’ like a desert absorbs water from the rain – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – Ubiquinol works for me. For decades, no one has known what causes myalgic encephalomyelitis (ME, commonly called ME/CFS). The study under review extends this line of research by examining the effects of ubiquinol-10, a lipid-soluble form of CoQ10, on clinical outcomes in patients with CFS. not sure – need to read more. This blog is one of a continuing series of blogs that are attempting to peer into the future and see what treatments possibly await us. (I think when I tried taking it alone in the past, I had a weird side-effect – my stool became lighter [sorry for the gross detail ] – which was perhaps suggestive of an effect on the liver, which I read could be a side-effect of B3). The group taking 300 mg of CoQ10 reported greater physical performance, reduced subjective fatigue and greater recovery compared to placebo while the 100 mg dose had no real effect. Then I discovered that my reaction to eating chocolate was that I became fat (! What about approaches targeting antioxidants? ( 8 ) CoQ10 targets a specific site of your cell’s energy production cycle where the largest amount of free radicals are produced. amzn_assoc_search_type = "search_widget"; Trying to force those complexes “to work correctly” seems very close to trying to override essential safeties to me. Free radicals are produced en masse during ATP production. Any research available on this? It is not intended as medical advice and should be used for informational purposes only. If you join together the amino acids l-histadine and beta-alanine, you get the dipeptide called carnosine. I have taken ubiquinol for years, and recently added a product called mitoQ (mitoquinol mesylate). It is common in patients of chronic fatigue syndrome Also seen in conditions which cause high amounts of noradrenaline to be produced. Chronic Fatigue Syndrome (ME/CFS) In 2016, the Watanabe group’s small (n=43) placebo-controlled, double-blinded study from Japan found that 150 mg/day of ubiquinol-10 (the reduced form of CoQ10) for 12 weeks improved autonomic nervous system and cognitive functioning. So this is a complex one.”. Our bodies are able to synthesize most of the CoQ10 we need, but we also get some from food, such as beef, broccoli, and eggs. For four to six weeks, also take the pregnenolone, CoQ10 and fish oil as described above. Required fields are marked *, HEALTH RISING IS NOT A 501 (c) 3 NON-PROFIT. If “dirty” energy production is occurring – as has been suggested in ME/CFS – CoQ10 might provide a way to clean up the mess and increase energy. Fluge and Mella, in their 2015 meatabolomic study , divided amino acids into three categories by where in the Krebb’s cycle they participate and discern which processes are being affected. The end result of all these little steps, if all goes well, is providing us with ATP. Research suggests that CoQ10 can benefit Chronic Fatigue Syndrome, a complex and baffling disease that incapacitates as many as half a million people in the US. I too have found that almost anything that helps, nimodipine, taurine, various high dose antioxidants, stops working. With virtually all ME/CFS patients, in particular, being unable to engage in strenuous exercise, anything to clean out the blood vessels may be a good idea. Here’s a Short 6 min video on the interesting phenomenon, How to Regenerate Coenzyme Q10 (CoQ10) Naturally | NutritionFacts The oil formulations increase drug solubility in the gut and enhance drug transport via the lymphatic system. Chronic fatigue syndrome (CFS) is a mysterious medical condition that affects approximately 500,000 Americans. I think HPM axis is so involved in so many regulatory function that damage…physical, psychological, viral, toxic, etc….can reset the default to hell. When I take CoQ10, I feel so much better for a couple of hours. This systematic review looked at whether vitamin D supplementation may help reduce the symptoms of atopic dermatitis. Excellent work as always. To date, reviews of treatment options have suggested that cognitive behavioral therapy[5] and graded exercise treatment[6] can reduce fatigue. Otherwise you overburden your body and can get into REAL trouble. That decreases the firing strength and potential of the neurons. The engine will make all sorts of weird noises. This idea stems from the fact that the enzyme can help with a variety of medical conditions. Chronic Fatigue Syndrome (ME/CFS) and FM Studies Maes (2009) found highly reduced levels of CoQ10 in CFS and that low CoQ10 levels were associated with increased symptoms. I take 200 mg twice at day (morning + evening) to get a 24 hour effect, https://www.jala-helsekost.dk/pharma-nord-bio-quinone-q10-180-kap.html?gclid=CjwKCAiA7939BRBMEiwA-hX5J5SdyGypgtQUuFCyC7YBQyBSRufXDO6NaDoO8SgN8ZGzdpEY0yvizxoCcWUQAvD_BwE. I have read that this is a possible side-effect, but wonder what is causing it. Lots of additional research linked in those comments that your body decrease as you age some doctors recommended as research! The first picture in it shows how these complexes cooperate you get the right! Highest quality products results are mostly encouraging research group many me patients, both of these future?... 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